The aim of present study was to prepare buccal disintegrating tablets of Captopril, a bitter drug by using super-disintegrants addition technique. Buccal disintegrating tablets of Captopril was prepared in order to increase patient compliance, good taste, rapid disintegration, enhancing bioavailability, reduce error in taking medication and offer more efficacy than conventional tablet. Also, effective taste masking achieved by formation of beta-cyclodextrin inclusion complex and evaluated spectrophotometrically. The blend was examined for physical property and then compressed using 8 mm flat punches. Nine formulation batches (F1-F9) were prepared using three different concentrations of superdisintegrants viz Crosscarmellose sodium, Crosspovidone and Sodium Starch Glycolate by direct Compression Method. The concentrations of superdisintegrant were fixed to 6 mg, 12 mg and 18 mg per 150 mg of total weight of tablet to optimize the formulation batches. Compressed tablet were evaluated for hardness, friability, weight variation, drug content and in vitro disintegration time, diffusion study and in vitro dissolution study. All formulations showed compliance with pharmacopoeial standards. The formulated tablets were then compared with the marketed preparation. Prepared batches (F4-F6) shows nearly comparable drug release with marketed tablets, it may be due to the presence of Crosspovidone. The tablets were then subjected to accelerated stability study as per ICH guidelines for the period of three month. Accelerated stability study condition shows negligible changes in drug release for the period of three months.
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